Liao X, et al. - Authors compared the effectiveness and safety profiles of different phosphodiesterase-5 inhibitors (PDE5Is) administrations for erectile dysfunction (ED) in diabetic men, including on-demand (PRN) and regular regimens (OAD). In diabetic men, PDE5I administrations were generally efficient and well-tolerated. Seemingly, among these administrations, vardenafil PRN and mirodenafil PRN have a possible advantage of efficacy and avoid adverse effects compared with others. PRN and OAD regimens of PDE5Is demonstrated no significant difference.