Emanuelsson F, et al. - In this prospective cohort study of the general population, researchers tested the premise that the risks of peripheral arterial disease (PAD) and chronic kidney disease (CKD) are elevated and that low ankle-brachial index (ABI) and estimated glomerular filtration rate (eGFR) are related to a high risk of myocardial infarction (MI) in people with clinical familial hypercholesterolemia (FH). Study participants included 106,172 people, among whom 7,109 received a diagnosis of FH. According to findings, individuals with clinical FH have increased risks of PAD and CKD, and a high risk of MI is associated with low ABI and eGFR. Individuals with FH should, therefore, be screened for PAD and CKD, and ABI and eGFR might be used as prognostic tools in the management and treatment of FH in order to identify those with a high risk of MI.