Schmilovitz-Weiss H, et al. - Using a retrospective design, researchers tested the applicability of the current reference range values of alanine aminotransferase (ALT) among community-dwelling individuals aged at least 65 years who were tested for serum ALT in 2002 at a large health management organization. These participants were then followed until the end of December 2012. Higher mortality risk was significantly associated with lower mean values of hemoglobin, albumin, and total cholesterol, both for patients with lower serum ALT levels (<10 IU/l) and patients with higher serum levels (>56 IU/l). In community-dwelling individuals of at least 65 years old, very low and very high levels of serum ALT within the current reference range were related to an increased risk of death.