Utzschneider KM, Tripputi MT, Kozedub A, et al. - In this study, model‐derived measures of β‐cell function were compared between youth and adults with either IGT or type 2 diabetes to determine if a β‐cell defect differentiates these age groups. Researchers designed a cross‐sectional analysis of baseline data from the Restoring Insulin Secretion Study including youth (54 Y‐IGT, 33 Y‐D) and adults (250 A‐IGT, 104 A‐D) who had undergone 3‐hour OGTTs for modeling of insulin secretion rates (ISRs), glucose sensitivity, and rate sensitivity. They quantified insulin sensitivity as the glucose infusion rate/insulin from a hyperglycemic clamp. This study's findings demonstrate that model‐derived measures of β‐cell function serve additional insight into the pathophysiology of type 2 diabetes in youth with higher ISRs and β‐cell secretion more responsive to glucose in youth relative to adults even after adjusting for differences in insulin sensitivity. It is unknown if these observations in youth reflect β‐cells that are healthier or if this is a defect that contributes to more rapid loss of function.