Bjornstad P, et al. - In adults with type 1 diabetes (T1D), researchers assessed the relationship between plasma biomarkers of kidney injury and intrarenal hemodynamic function (glomerular filtration rate [GFR], effective renal plasma flow, and renal vascular resistance). Study participants included patients with longstanding T1D (≥ 50 years duration); 44 diabetic kidney disease (DKD) resistors (eGFR > 60mL/min/1.73m² and < 30mg/day urine albumin excretion) and 22 with DKD, in addition to 73 control participants. In T1D, elevated neutrophil gelatinase-associated lipocalin (NGAL) was found to be related to intrarenal hemodynamic dysfunction. In adults without T1D, elevated NGAL and β2 microglobulin were found to be related to intrarenal hemodynamic dysfunction. Study findings indicated that it may be possible to define a diabetes-specific interplay between tubular injury and intrarenal hemodynamic dysfunction.