Bjerregaard MR, et al. - Researchers investigated the indications currently used for fluid resuscitation and the effect of fluid on these indications in patients with septic shock admitted to the intensive care unit (ICU) via performing a post hoc analysis of the CLASSIC trial, where patients with septic shock were randomized to fluid restriction or standard care. Findings revealed that low blood pressure levels, high lactate, and low urinary output were the most frequent indications for fluid in ICU patients with septic shock. No clear effects of fluids, when given on these indications, were evident; however, these may correlate to the time course of sepsis resuscitation.