van Santen DK, et al. - Given that the incidence and prevalence of hepatitis C virus (HCV) infection among people who use drugs (PWUD) peaked in the 1980s in Amsterdam, researchers evaluated the relationship between liver stiffness measurement and sociodemographic, clinical and behavioral determinants in all PWUD and chronic (cHCV)-infected PWUD. Data showed a high proportion of PWUD had significant fibrosis or cirrhosis that were related to cHCV infection, HIV/HCV coinfection, and duration of heavy alcohol drinking. To decrease the liver disease burden in this population, increased uptake of HCV treatment and interventions to reduce alcohol use are warranted.