Subramaniam N, et al. - In light of the American Joint Committee on Cancer’s (AJCC) eighth edition incorporating depth of invasion into TNM classification of oral cavity squamous cell carcinoma (SCC) (due to the prognostic impact on recurrence and survival), authors sought to study the effect of adverse pathological features (perineural invasion [PNI], lymphovascular invasion, and differentiation) on overall survival (OS) after reclassifying the patients with T1 to T2 oral cavity SCC, according to these recommendations. Prognostic outcome in oral cavity tumors classified as T1 to T2 as per the new AJCC eighth edition was better reflected by the incorporation of PNI and differentiation. Worse survival was seen with increasing adverse pathological features.