Masala G, et al. - In the randomized 2x2 factorial DAMA trial, researchers assessed the impact of 24-month dietary and/or physical activity (PA) interventions on mammographic breast density (MBD) in healthy post-menopausal women. Participants were aged 50-69 years, non-smokers, with MBD > 50% and no recent hormone therapy. They were randomized to a dietary intervention focused on plant-foods with a low glycemic load, low in saturated fats and alcohol; a PA intervention combining daily moderate intensity activities, and one weekly supervised session of more strenuous activity; both interventions; or general recommendations. Findings suggested that a 24-months dietary or PA intervention may attenuate MBD in postmenopausal women.