Kim Y, et al. - A prospective cohort study was conducted to assess the relationship of weight change and baseline body mass index (BMI) with fibrosis progression in young and middle-aged adults with non-alcoholic fatty liver disease (NAFLD). Participants in the study were 40,700 adults with NAFLD in Korea who had regular health screening exams and were followed for a median 6.0 years. Based on aspartate aminotransferase to platelet ratio index (APRI), obesity and weight gain are independently correlated with increased risk of fibrosis progression. In individuals with NAFLD, sustaining a normal healthy weight and avoiding weight gain might help reduce fibrosis progression.