Amiano P, et al. - In the Spanish Multicase-Control Study, researchers assessed the association between dietary non-enzymatic antioxidant activity (NEAC) and colorectal cancer (CRC) risk, accounting for the possible impact of coffee and other dietary factors, in 1,718 CRC cases and 3,312 matched-controls. For three methods, dietary NEAC was estimated using published values of NEAC content in food, with and without coffee’s NEAC. They also used unconditional logistic regression models adjusted for lifestyle and dietary factors to compute odds ratios and 95% confidence intervals. Findings demonstrated decreased CRC risk related to intake of an antioxidant-rich plant-based diet, both with and without NEAC from coffee.