Tsounapi P, et al. - Researchers assessed the impacts of a micronutrient supplementation (MS) combined with avanafil on sperm function. They treated the oligoasthenospermic men daily for 90 days with either an MS, l-carnitine, MS plus avanafil or avanafil; another group of 42 men with oligoasthenospermia (Group E) received no treatment. Results demonstrated that sperm membrane permeability with an overall result improvement in sperm motility, outcome of hypoosmotic swelling test (HOST) and increase in the percentage of hyperactivated spermatozoa were improved with MS or MS plus avanafil combined administration or avanafil alone.