Teló GH, et al. - Researchers examined trajectories of daily insulin dose requirements and glycemic control in children, adolescents and young adults with Type 1 diabetes, as well as factors correlated with changing insulin needs and deterioration in HbA_1c. This study was conducted on 635 children, adolescents and young adults with Type 1 diabetes. Insulin dose was higher in girls at ages 8–13 years, but higher in boys/young men at ages 16–21 years. Compared with injection therapy, pump therapy was associated with lower insulin dose at ages 8–24 years and lower HbA1c at ages 8–22 years. In young people with Type 1 diabetes, this longitudinal assessment identified clinically meaningful modifiable (e.g. insulin regimen) and non-modifiable (e.g. sex) factors predictive of insulin requirements and HbA_1c levels. Glycaemic control could be improved by anticipatory insulin adjustments.