Maritz M, et al. - Researchers evaluated which biomarkers (metabolic, inflammatory, endothelial activation, and oxidative stress) are associated with aortic stiffness in young and older black South Africans who self-reported no alcohol-use. Cross-sectional data from young (aged 24.7 ± 3.24 years) black adults partaking in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension (African-PREDICT) study (N=216) and five-year follow-up data from older (aged 61.6 ± 9.77 years) black adults (N=322) taking part in the South African leg of the Prospective Urban and Rural Epidemiology study, conducted in the North West Province (PURE-SA-NWP) was incorporated. In older black adults, dysglycemia independently forecast aortic stiffness after five years. In preventing early vascular ageing and subsequent cardiovascular disease development in Africa, life-course management of body weight and sugar intake was important.