Lee VY, et al. - Researchers assessed the impact of exercise on vaccine-related pain, anxiety and fear in adolescents, during a school-based program for HPV vaccinations wherein students (Female: 61, Male: 55) aged 11–13 years were randomly allocated to either an Exercise or Control group. Before receiving the vaccine according to usual care, all participants were asked to complete the demographic and Trait-anxiety questionnaires and the Exercise group was also asked to performed upper body exercise for 15 min. All patients were inquired immediately after the vaccine administration for pain, anxiety and fear at the time of receiving the vaccine. Findings supported the use of exercise prior to vaccine administration. This was particularly noted in female adolescents who were specifically vulnerable to negative experiences during vaccination procedures. Taking into account the ease of application, as well as the benefit of exercise, the use of simple exercise prior to vaccination in mass vaccination settings was supported.