Doll MK, et al. - Researchers determined the overall impact of the Quebec rotavirus vaccine program (launched in November 2011) and the impact for each 10% increase in rotavirus vaccine coverage on pediatric, all-cause acute gastroenteritis hospitalizations using binomial regressions adjusted for seasonality, long-term trends, and infection dynamics. They estimated the impact of the vaccine program as: 1) a dichotomous variable, representing program presence/absence, and linear term to account for changes in trend in the post-program period, or 2) a continuous variable, representing rotavirus vaccine coverage. They found that the vaccine program was found to be related to a 51.2% relative decline in adjusted weekly all-cause acute gastroenteritis hospitalization rates when using exposure 1). A 10% increase in rotavirus ≥1-dose coverage was found to be related to a 7.1% relative decline in adjusted weekly rates when using exposure 2). As an addition to standard measurement of the overall effect, the possible utility was suggested of estimation of the overall effect attributable to a change in vaccine coverage.