Ludwig VM, et al. - Authors inspected the connection between depressive symptoms with reduced physical activity (PA) in individuals at high risk of developing cardiovascular disease (CVD) among adults, aged 49–74 years, 86% male at high (≥20%) risk of developing CVD in the next 10 years as defined via QRISK2 score. Candidates with mild depressive symptoms and those with moderate to severe depressive symptoms walked 13.3% and 15.6% less compared to non-depressed individuals, respectively, after controlling for age, gender, ethnicity, education level, body mass index (BMI), smoking, consumption of alcohol, day of the week and season. Data illustrated that male gender, white ethnicity, higher education level, lower BMI, non-smoking, moderate alcohol intake, weekdays and summer season exhibited an independent link with higher step count. The inference drawn was that subjects at high risk of CVD with depressive symptoms presented with lower levels of PA.