Di Battista AP, et al. - Given that combining blood biomarker analysis with advanced neuroimaging may help elucidate important secondary injury mechanisms and validate their continued utility in brain injury research, researchers herein assessed co-modulation between peripheral blood biomarkers and advanced functional brain imaging after sport-related concussion (SRC). In both recently concussed athletes and healthy athletes with a history of concussion, strong links between peripheral blood biomarkers and Magnetic Resonance Imaging (MRI) measures were found. The continued implementation of blood biomarkers as a tool to investigate brain injury, particularly in a multimodal framework, was supported. This work further support that human concussion is associated with inflammation, oxidative stress, and cellular damage, and that physiological perturbations may extend chronically beyond recovery.