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Efficacy of a bivalent killed whole-cell cholera vaccine over five years: A re-analysis of a cluster-randomized trial

BMC Infectious Diseases Feb 27, 2018

Fong Y, et al. - Given the feasibility of oral cholera vaccine (OCV) in preventing or mitigating cholera outbreaks, researchers sought to assess better understanding of the vaccine’s efficacy among different age groups and how rapidly its protection wanes. They observed the vaccine efficacy of 38% for those vaccinated from ages 1 to under 5 years old, 85% for those 5 to under 15 years, and 69% for those vaccinated at ages 15 years and older. During the trial, efficacy did not appear to wane among adult vaccinees, but there was insufficient data to assess the waning of efficacy among child vaccinees. Findings there revealed a statistically significant difference in OCV efficacy when the vaccine was administered to children under 5 years old vs children 5 years and older.
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