Zaazaa A, et al. - This research was formulated in order to evaluate the effect of varicocelectomy and/or mast cells (MCs) stabilizer on sperm DNA fragmentation in infertile men with varicocele (Vx). A substantial improvement was achieved in the sperm DNA fragmentation index (DFI) due to surgical repair followed with MCs stabilizer compared with either surgical repair or MCs stabilizer alone, in infertile men associated with Vx and high sperm DFI.