Kusawake T, et al. - Any potential interactions between amenamevir and ketoconazole, rifampicin, midazolam, or warfarin in healthy male participants was ascertained in this study. These outcomes affirm that amenamevir (as a cytochrome P450 3A4 substrate) can interact with ketoconazole or rifampicin, and (as a cytochrome P450 3A4 inducer) can interact with midazolam; however, no interaction between amenamevir and (S)-warfarin was found, showing that amenamevir is not an inducer of cytochrome P450 2C9.