Tsourlakis MC, et al. - FOXA1 had been identified as a transcription factor involved in androgen signaling with relevance for lineage specific gene expression of the prostate. Authors here aimed at investigating FOXA1 expression by immunohistochemistry on a tissue microarray containing 11,152 prostate cancer specimens. As per findings, high expression of FOXA1 was an independent prognostic parameter in ERG negative prostate cancer. Thus suggesting that FOXA1 measurement could provide clinically useful information in prostate cancer.