Moyal L, et al. - The intent here was to illustrate the mechanism underlying the effect of AN-7 on Dox-induced double-strand DNA breaks (DSBs) in cutaneous T-cell lymphoma (CTCL), MyLa and Hut78 cell lines. It was reported that AN-7 sensitized the CTCL cell lines to Dox, and when combined with Dox. It also sustained unrepaired DSBs by suppressing repair protein expression. A mechanistic rationale was yielded for combining AN-7 with Dox or other DSB inducers as a therapeutic modality in CTCL.