Ma Y, et al. - The efficacy of traditional Chinese medicine (Suoquan) and Western medicine (desmopressin) was examined for the management of nocturnal enuresis (NE) in children. Results suggested that the combined treatment of traditional Chinese and Western medicines was effective and offered a low relapse rate in children with NE. The major predictive factors for the complete response after treatment were the NE frequency, treatment method, and age.

Methods

• In this study, 369 children with NE were randomized to receive treatments consisting of Suoquan, desmopressin plus Suoquan, desmopressin, or behavioral interventions for two months.
•  The response rate of each group was analyzed.
• With the aid of logistic regression analysis, the viable demographic factors that could lead to success were examined.
• After 3 months of follow-ups, the relapse rate was investigated.

Results

• Findings displayed that the complete response rate in desmopressin plus Suoquan (37.5%) was higher than the group of behavioral interventions (6.3%, P<0.007).
• Children on desmopressin group displayed a lower complete response rate (22.5%) and a higher nonresponse rate (25.0%) compared with those on desmopressin plus Suoquan (nonresponse rate 21.9%, P>0.007).
• The relapse rate in desmopressin was significantly higher than the group of desmopressin plus Suoquan (72.2% vs. 30.6%, P<0.007). 
•  Multivariate analysis revealed that the treatment group, NE frequency and age were independent predictors of complete response at 2 months (P<0.05).