Branche BL, et al. - Researchers in Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study examined the relationship between sleep problems measured by the Medical Outcomes Study Sleep Scale (MOS-Sleep) 6-item survey and LUTS development and progression. Among men with LUTS, there appeared an association of worse sleep scores with LUTS progression. Among asymptomatic men, worse sleep scores seemed related to LUTS development. These data suggested sleep problems could precede LUTS. Further study is required to assess whether treating sleep problems could improve LUTS.