Goffin K, et al. - An inspection was conducted of the performance of ^99mTc-trofolastat SPECT/CT in patients with intermediate- and high-grade prostate cancer (PCa), before radical prostatectomy and extended pelvic lymph node (LN) dissection, with histopathology as the gold standard. It was observed that ^99mTc-trofolastat SPECT/CT detected PCa with high sensitivity in patients with intermediate- and high-risk PCa compared with histology. It exhibited the potential of being used as a surrogate marker for Gleason scores (GS) and predict LN involvement (LNI).