Sokhal AK, et al. – Here, the clinicians intend to inquire sexual dysfunction and enlargement of seminal vesicles in sexually active male who were treated by α1–blockers for benign prostatic hyperplasia and its possible clinical application. It was suggested that alpha blockers as silodosin, tamsulosin and alfuzosin are a safe and effective tool in BPH for improving LUTS and quality of life. Remarkably, loss of seminal emission with α–blockers appears the cause of seminal vesicles enlargement. In addition, the exact mechanism of these findings requires further clinical and experimental research.