Bhardwaj R, et al. – Aim of this study was to evaluate the linkage of hyperoxaluria–induced reactive oxygen species (ROS) generation with endoplasmic reticulum (ER) stress by inhibiting the later with 4–Phenylbutyric acid (4–PBA). Researchers demonstrated the major role of ER in hyperoxaluric manifestations thereby providing an opportunity to target ER stress for future therapeutic interventions.