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Effect of endoplasmic reticulum stress inhibition on hyperoxaluria-induced oxidative stress: Influence on cellular ROS sources

World Journal of Urology Aug 31, 2017

Bhardwaj R, et al. – Aim of this study was to evaluate the linkage of hyperoxaluria–induced reactive oxygen species (ROS) generation with endoplasmic reticulum (ER) stress by inhibiting the later with 4–Phenylbutyric acid (4–PBA). Researchers demonstrated the major role of ER in hyperoxaluric manifestations thereby providing an opportunity to target ER stress for future therapeutic interventions.
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