Qiao Y, et al. – The aim of the present study was to explore the relationship in between the daily consumption of fish oil (360 mg DHA + 540 mg EPA), and reduction of symptoms and violent behavior among patients with schizophrenia. According to the findings obtained, violent schizophrenia patients treated with fish oil (360 mg DHA + 540 mg EPA) showed a reduction in violence, but improvement in positive and negative symptoms was no greater than patients treated with the placebo after 12 weeks.

Methods

• In a twelve week, double-blind supplementation trial, 50 inpatients meeting ICD-10 criteria for schizophrenia and scoring more than four of Modified Overt Aggression Scale (MOAS) with antipsychotics treatment were randomly assigned to receive either fish oil (N = 28) or a placebo (N = 22).
• After that, assessments were performed at baseline and at weeks 4, 8 and 12

Results

• The results of this study showed that the PANSS and CGI scores diminished at the week of 4, 8 and 12, however, no differences were found between the 2 groups.
• Findings revealed that MOAS scores declined significantly at weeks 4, 8 and 12.
• In addition, MOAS scores of the fish oil group declined significantly than the placebo group (t = -2.40, P < 0.05) at week 12.