Carbone J et al. – This study evaluated 51 genes associated with the complement pathway to examine their relationship with antibody–mediated rejection (AMR) in a small number of heart recipients. The 2 single nucleotide polymorphisms (SNPs) associated with the absence or presence of AMR were p.Gly54Asp–MBL2 in the mannose–binding lectin (MBL) 2 gene and p.Asn428 (p=)–CFP in the alternative complement factor properdin (CFP) gene, respectively. These observations suggest that the circulating levels of selected proteins of both the lectin and alternative complement pathways may get influenced by complement SNPs, thus revealing which patients will develop AMR.