Srisawat N, et al. – The physicians performed this feasibility study to examine whether early renal replacement therapy (RRT) initiation guided by plasma neutrophil gelatinase–associated lipocalin (pNGAL) could improve acute kidney injury (AKI) outcome. They proposed that it was feasible to use pNGAL to triage severe AKI patients. However, in this high–risk group, early initiation of RRT did not affect the 28–day mortality.