Dell’Oglio P, et al. – An analysis was designed to evaluate whether even in the group of localized renal cell carcinoma (RCC), some patients might harbor a disease with a predilection for lymph node invasion (LNI) and/or lymph node (LN) progression and might deserve lymph node dissection (LND) at the time of surgery. The results of this study showed that LNI and/or LN progression is a rare entity in patients with localized RCC. However, patients with larger tumors might still benefit from LND because of a non–negligible risk of LNI and/or LN progression.