Park SK, et al. – Researchers intended to assess the incidental risk for type 2 diabetes (T2DM) according to 2–hour plasma glucose (2–hr PG) level of oral glucose tolerance test (OGTT) and phenotype of impaired glucose tolerance (IGT). The results of this study suggested that the highest level of 2h–PG(180–199mg/dL) in IGT and IGT with IFG were strong predictor for T2DM. 2–hr PG of 120–139 mg/dL was more significantly correlated with T2DM within NGT, and male was more susceptible for T2DM than female.

Methods

• In this study, 7,654 Korean participated in the Korean Genome and Epidemiology Study (KoGES) were stratified by 2–hr PG levels of OGTT, and followed up for 63,665 person–years.
• They applied cox proportional hazards model to compute the hazard ratios (HRs) and 95% confidential interval (CI) for T2DM according to 2–hr PG levels of OGTT with adjustment for multiple covariates.
• They conducted subgroup analysis by gender and the presence of impaired fasting glucose (IFG) or not.

Results

• In context of the findings, within IGT, the adjusted HRs for T2DM significantly increased proportionally to 2–hr PG level [<140 mg/dL: reference, 140–159 mg/dL: 3.07 (2.67 – 3.54), 160–179 mg/dL: 5.44 (CI 4.66 – 6.34), 180–199 mg/dL: 7.91 (CI 6.53–9.59)].
• The evidence showed that IGT combined with IFG had the profoundly increased HRs than isolated IFG.
• Even within normal glucose tolerance (NGT), 2–hr PG level ≥120 mg/dL had the higher risk for T2DM than other NGT groups.
• These correlations were more dominant in male than female.