Andersen RK, et al. – An elucidation was entailed of the association of biological and other factors with Hidradenitis suppurativa (HS) patient's self–assessed health as reflected by the EQ5D VAS score. A link was noted between smoking and the highest change in VAS score, but a Major Depression Inventory (MDI) of 10 (lower than study average) or a body mass index (BMI) of 40 affected the results more. It yielded an estimate of how much BMI and smoking, in association with other factors, related to the self–evaluated health state of HS patients. Hence, they could be relevant contextual factors to the construction and interpretation of specific patient reported outcome measures. In order to improve the quality of life (QoL), smoking cessation and weight loss, and advice active screening for depression were recommended, owing to 10% of the study cohort qualifying for a depressive diagnosis according to ICD–10.