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The safety issues and hardware-related complications of deep brain stimulation therapy: A single-center retrospective analysis of 478 patients with Parkinson’s disease

Clinical Interventions in Aging Aug 12, 2017

Zhang J, et al. – This paper entailed the assessment of hardware–related complications and the causes of unnatural death, in patients with Parkinson’s disease (PD) who were treated with deep brain stimulation (DBS). Deaths among such patients were unrelated to the disease itself or complications associated with the surgery. Pneumonia, malignant tumors, asphyxia, and multiple–organ failure were reported as the common causes of death. Swallowing–related problems could be the most significant clinical symptom in late–stage PD, as they could not be stabilized or improved by DBS alone. They were known to be potentially lethal. Despite prophylactic antibiotics and steroids or antihistamine drugs aided in reducing the risk of infection, the detection of high–risk patients was essential, for whom a therapeutic approach not requiring an implantable device was more suitable.
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