Based on the findings, it was inferred that turmeric cream can be employed as an alternative option or adjuvant treatment in mild to moderate vitiligo lesions and in those who cannot tolerate the adverse impacts of conventional therapies.

• This study enrolled 30 eligible patients to assess the efficacy of topical turmeric cream on vitiligo’s lesions appearance including size and repigmentation.

• Patients were instructed to apply turmeric and placebo cream at the specified side of their body twice a day for 4 months; 24 patients completed the trial.

• Compared with placebo, turmeric cream decreased the size of lesions and improved lesion‘s appearance significantly.

• Higher patient’s satisfaction score was obtained with turmeric cream vs placebo.