Houard L, Amzulescu MS, Colin G, et al. - The present study was performed to assess the additional prognostic value of pulmonary transit time (PTT) in heart failure with decreased ejection fraction over other well-validated predictors of risk including the Meta-Analysis Global Group in Chronic Heart Failure risk score and ischemic cause. Researchers prospectively reviewed 410 patients with chronic heart failure with reduced ejection fraction (61±13 years, left ventricular (LV) ejection fraction 24±7%) who had undergone a clinical cardiac magnetic resonance (cMR) to assess the prognostic value of PTT for a primary endpoint of overall mortality and the secondary composite endpoint of cardiovascular death and heart failure hospitalization. They assessed normal reference values of PTT in a population of 40 asymptomatic volunteers free of cardiovascular disease. This study’s findings demonstrated that, despite limitations in temporal resolution, in patients with heart failure with reduced ejection fraction, PTT derived from first-pass perfusion imaging provides higher and independent prognostic information than clinical and other cMR parameters, including LV and right ventricular ejection fraction or feature tracking global longitudinal strain.