Mendoza M, Garcia‐Manau P, Arévalo S, et al. - In this study, the ability of first‐trimester combined screening for pre‐eclampsia (PE) was compared to prognosticate early‐onset and preterm PE when pregnancy‐associated plasma protein‐A and placental growth factor were evaluated before vs after 11 weeks' gestation. Between October 2015 and September 2017, researchers performed a secondary analysis of a prospective cohort study of singleton pregnancies undergoing routine first‐trimester screening conducted at Vall d'Hebron University Hospital, Barcelona, Spain. They noted demographic characteristics, obstetric history, maternal history, and biophysical markers (mean uterine artery pulsatility index and mean arterial blood pressure) at the first‐trimester scan (at 11 + 0 to 13 + 6 weeks' gestation). A total of 2641 women were included in the study. The results of this study demonstrated that the prognostication of early‐onset and preterm PE is similar when serum biomarkers are assessed before or after 11 weeks. For PE risk assessment, this allows the use of a two‐step approach that permits immediate risk calculation at the time of the first‐trimester scan.