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Preoperative BMI predicts postoperative weight gain in adult-onset craniopharyngioma

Journal of Clinical Endocrinology and Metabolism Jan 14, 2021

Duan D, Wehbeh L, Mukherjee D, et al. - Although benign, craniopharyngiomas are identified to have the highest morbidity of all non-malignant sellar tumors. In this study, postsurgical weight and metabolic outcomes in adult-onset craniopharyngioma (AOCP) were investigated via performing retrospective chart review of AOCP patients who underwent surgery between Jan 2014- May 2019. In addition, researchers sought the clinical predictors of weight gain. Among 45 AOCP patients with a minimum follow-up of 3 months, higher measures of both weight and BMI were recorded at last follow-up. Higher postoperative weight gain was reported for those with a lower BMI at the preoperative visit in this AOCP cohort. They noted increase in pituitary deficiencies postoperatively, with 58% of patients having ≥ 3 hormonal deficiencies. Higher postoperative weight gain was also reported in patients with ≥ 3 hormonal deficiencies at last follow-up.

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