Bura V, Caglic I, Snoj Z, et al. - This study was undertaken to investigate the multiparametric MRI (mpMRI) appearances of normal peripheral zone (PZ) across age groups in a biopsy-naïve population, where prostate cancer (PCa) was subsequently excluded, and propose a scoring system for background PZ changes. Researchers conducted a retrospective study including 175 consecutive biopsy-naïve patients (40–74 years) referred with a suspicion of PCa, but with subsequent negative investigations. The results of this study demonstrated that in younger individuals, the normal PZ demonstrates significantly lower T2WI signal intensity, lower apparent diffusion coefficient values, and diffuse enhancement on dynamic contrast-enhanced imaging, which may hinder diagnostic interpretation in these individuals. The results highlighted that the proposed standardized PZ background scoring system may help convey the potential for diagnostic uncertainty to clinicians.