Khutok K, Janwantanakul P, Jensen MP, et al. - In individuals with chronic low back pain, researchers conducted this prospective cohort study evaluating responsiveness and estimating the minimal clinically important differences (MCIDs) for the Patient-Reported Outcomes Measurement Information System-29 (PROMIS-29) scales. Validated Thai versions of the study measures were used to conduct this study in physical therapy clinics in Thailand. The PROMIS-29 was completed by 183 individuals with chronic low back pain at baseline and at 4-weeks follow-up. A 7-point measure of Global Perceived Effect (GPE) was used to assess perceived change in each domain assessed by the PROMIS-29 scales at 4 weeks. In the study sample, the most responsivity was reported for the PROMIS-29 scale scores assessing pain intensity, physical function, and anxiety. In light of the findings from other investigators, these results support 5.0 points as a reasonable MCID for most of the PROMIS-29 scales.