Engen MJ, Lyngstad SH, Ueland T, et al. - Although negative genetic associations have been described between schizophrenia and general cognitive ability in recent studies, there remains uncertainty concerning the correlation between polygenic risk for schizophrenia and individual cognitive phenotypes. Researchers here assessed 731 participants with a psychotic disorder and 851 healthy controls for the correlation between a polygenic score (PGS) for schizophrenia and six well-defined cognitive domains as well as for a composite measure of cognitive ability and a measure of premorbid intellectual ability. In addition, they examined the correlation between a PGS for general cognitive ability and the same cognitive domains in the same sample. Overall findings suggested that there are no associations between PGS for schizophrenia and PGS for general cognitive ability with cognitive performance in participants with psychotic disorders which indicate a possible role of either environmental factors or unassessed genetic factors in the development of cognitive impairments in psychotic disorders.