Lim KK, Lee VSY, Tan CS, et al. - The present study was conducted in Singapore to assess if the excess risks of coronary heart disease (CHD), stroke, dialysis, and lower extremity amputation (LEA) correlated with type 2 diabetes mellitus (T2DM) vary at all across age, sex, and ethnicity. Researchers matched individuals with T2DM applying nearest neighbor matching, to those without in 1:2 ratio utilizing 10-year administrative data. They generated interaction terms of age, gender, and ethnicity with T2DM status in Cox proportional hazard (PH) models to analyze if the excess risks were heterogeneous across age, gender, and ethnicity. Around 1 million person-years were included in the study, comprising 66,099 and 120,485 individuals with and without T2DM, respectively. The results of this study illustrated that excess risks of CHD, stroke, dialysis, and LEA correlated with T2DM were heterogeneous across some demographic subgroups. With older age, the association of T2DM with stroke and LEA were lower. Women had consistently higher associations of T2DM with CHD and stroke vs men.