Cuellar-Tamez RX, Villarreal-Calderon JR, Rubio-Infante N, et al. - Via performing a prospective observational study in patients treated with bariatric surgery, researchers examined the influence of bariatric-surgery-induced weight loss on the systemic inflammatory state linked with B cell activation molecules. Total plasmatic IgG levels showed a significant reduction, which could be linked with reduced B cell activity. Accordingly, a significant reduction in the B cell activating factors, such as APRIL, BAFF, and soluble CD40L, occurred and the inflammatory markers hs-CRP, IL-1β, IL-12, IL-18, and IFN-γ showed a general improvement. Findings are thus suggestive of reduced B cell activity after weight loss due to bariatric surgery. In addition, they could be the initial link among the systemic inflammatory factors, and B cell activation in this inflammatory context that results in IgG production and, potentially, to autoimmunity in cases with severe obesity.