Chen EY, Eickhoff SB, Giovannetti T, et al. - Researchers conducted a GingerAle meta-analysis of 25 voxel-based morphometry studies including 7,612 individuals to assess the impact of obesity on the orbitofrontal cortex. There was an association between greater body mass index and reduced orbitofrontal cortex gray matter volume. The data indicate the importance of the orbitofrontal cortex structure and functioning in neural models of obesity. The data imply more studies are required that analyze the functional significance of reduced orbitofrontal cortex gray matter volume in obesity, and the impact of age and weight changes on this relationship using longitudinal designs.