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Association of SARS-CoV-2 test status and pregnancy outcomes

JAMA Sep 30, 2020

Ahlberg M, Neovius M, Saltvedt S, et al. - Pregnant women in labor who were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were compared with those uninfected with respect to pregnancy outcomes. From March 25 to July 24, 2020, researchers identified 2,682 patients presenting in labor at Karolinska University Hospital, Stockholm, Sweden; of these, 156 (5.8%) were SARS-CoV-2 positive (142 [91%] at admission and 14 [9%] during pregnancy). Findings revealed that in women in labor, there was positive correlation of SARS-CoV-2 test positivity with a higher prevalence of preeclampsia and lower prevalence of induction of labor. Although COVID-19 is primarily a respiratory infection, it has systemic effects as well that may resemble preeclampsia. In concordance with results of 2 previous studies using comparators, there was the absence of an increased prevalence of preterm birth. The groups did not differ in Apgar scores and birth weight for gestational age; this finding is similar to that noted in a US study. Other accumulating data have already made it clear that in pregnancy, COVID-19 is less severe than the 2 previous coronavirus infections: severe acute respiratory syndrome–related coronavirus (SARS) and Middle East respiratory syndrome–related coronavirus (MERS). 

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