van der Toorn JE, Rueda-Ochoa OL, van der Schaft N, et al. - Researchers evaluated gender-specific cardiovascular risk profiles as well as death risk related to arteriosclerosis. A total of 2,357 participants (mean age 69 years, 53% women) from the population-based Rotterdam Study were examined by performing non-contrast computed tomography. In both genders, three cardiovascular risk profiles were unveiled by principal component analysis: (1) anthropometry, glucose, and HDL cholesterol; (2) blood pressure; and (3) smoking and total cholesterol. Strongest links were identified for profile 2 with severe ECAC (extracranial carotid artery calcification) and intracranial carotid artery calcification and for profile 3 with severe at all locations, except AVC (aortic valve calcification), in females. The strongest links were observed for profile 2 with vertebrobasilar artery calcification and profile 3 with severe aortic arch calcification among males. The strongest, independent links with cardiovascular death were demonstrated by ECAC and AVC in women and coronary artery calcification in men. Overall, findings further highlight that gender- and location-specific disparities exist in the etiology as well as consequences of arteriosclerosis.