Dhingra U, Kisenge R, Sudfeld CR, et al. - Experts aspired to explore whether lower zinc doses (5 mg or 10 mg per day), as compared with the standard zinc dose (20 mg per day), would be noninferior with respect to treatment efficacy but superior with respect to the side-effect profile (ie, vomiting). Four thousand five hundred children in India and Tanzania were randomly assigned who were 6 to 59 months of age and had acute diarrhea to receive 5 mg, 10 mg, or 20 mg of zinc sulfate for 14 days. Data reported that the percentage of children with diarrhea for more than 5 days was 6.5% in the 20-mg group, 7.7% in the 10-mg group, and 7.2% in the 5-mg group. According to findings, lower zinc doses were non-inferior in efficacy to treat childhood diarrhea and were associated with less vomiting than the standard 20 mg dose.