Fei Q, Li X, Lin J, et al. - Different expression profiles of long non-coding RNAs (lncRNAs) and mRNAs were investigated between male osteoporosis and normal control via performing high throughput RNA sequencing. Researchers obtained totally, 3,296 DEGs, 204 DElncRNAs and 168 DElncRNAs-nearby targeted DEGs pairs. The DElncRNAs–DEGs interaction network in male osteoporosis led to attaining of several interaction pairs including SNHG5-SYNCRIP-HBA1-HBB, HCG27-HLA-C, LINC02009-CCR2, and LOC101926887-IFIT1-IFIT2/IFIT3/IFIT5. The expression of LINC02009 and CCR2 was down-regulated in keeping with the RNA sequencing data. Observations suggest a possible involvement of the identified DElncRNAs–DEGs interaction pairs in the development of male osteoporosis, which make a contribution to underlying the mechanism of male osteoporosis. Among which, the validated DElncRNAs-nearby targeted DEGs interaction pair of LINC02009-CCR2 may be relevant regulators in the development of osteoporosis in males.