Yuan P, Lin L, Zheng K, et al. - In this hospital-based, 1:1 matched case–control study, researchers sought to analyze the connections between gastric cancer and serum pepsinogen I (PG I), PG II, PG I/II ratio, gastrin 17 (G-17) and Helicobacter pylori infection, and to examine dietary and lifestyle risk factors for gastric cancer in Fujian Province, China. In total, 180 pairs of patients with gastric cancer and control subjects were selected in the study, including 134 (74.4%) male pairs and 46 (25.6%) female pairs. According to results, serum PG II and G-17 levels and H. pylori infection rate were higher in patients with gastric cancer than in control individuals, whereas PG I/II ratio was lower in patients with gastric cancer. Findings sugested that serum PG, G-17 and H. pylori antibodies could be useful indicators for early detection of gastric cancer. Increased serum G-17 levels can indicate the location of gastric cancer. The clinical stage might include an increase in the serum PG II level and a decrease in the PG I/II ratio. Eating hot food, eating pickled vegetables and sometimes feeling distracted can be risk factors for gastric cancer while eating fresh fruits, eating onion or garlic, and drinking tea can be protective factors against the disease.